Morgan Lab

Jacquel, B., Kavčič, B., Aspert, T., Matifas, A., Kuehn, A., Zhuravlev, A., Byckov, E., Morgan, B., Julou, T. and Charvin, G.(2025)

A trade-off between stress resistance and tolerance underlies the adaptive response to hydrogen peroxide Cell Systems 16(7):101320

Niemeier, J-O., Roma, L.P., Riemer, J., Schwarzländer, M. and Morgan, B.(2025)

Monitoring subcellular NADP redox state with NAPstar biosensors Trends in Biochemical Sciences 50(8):733-734

Zimmermann, J., Lang, L., Calabrese, G., Laporte, H., Amponsah, P.S., Michalk, C., Sukmann, T., Oestreicher, J., Tursch, A., Peker, E., Owusu, T.N.E., Weith, M., Roma, L.P., Deponte, M., Riemer, J. and Morgan, B.(2025)

Tsa1 is the dominant peroxide scavenger and a source of H2O2-dependent GSSG production in yeast Free Radical Biology and Medicine 226:408-420

Scherschel M, Niemeier J-O, Jacobs LJHC, Hoffmann MDA, Diederich A, Bell C, Höhne P, Raetz S, Kroll JB, Steinbeck J, Lichtenauer S, Multhoff J, Zimmermann J, Sadhanasatish T, Rothemann RA, Grashoff C, Messens J, Ampofo E, Laschke ME, Riemer J, Roma LP, Schwarzländer M, Morgan B.(2024)

A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes Nature Communications 15(10704) Image for A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes

Image for A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes

Castro, H., Rocha, M.I., Duarte, M., Vilurbina, J., Gomes-Alves, A.G., Leao, T., Dias, F., Morgan, B., Deponte, M. and Tomás, A.M.(2024)

The cytosolic hyperoxidation-sensitive and -robust Leishmania peroxiredoxins cPRX1 and cPRX2 are both dispensable for parasite infectivity Redox Biology 71:103122

Fabian Geissel, Lukas Lang, Britta Husemann, Bruce Morgan, Marcel Deponte.(2024)

Deciphering the mechanism of glutaredoxin-catalyzed roGFP2 redox sensing reveals a ternary complex with glutathione for protein disulfide reduction Nature Communications 15(1):1733

Bischoff, E., Lang, L., Zimmermann, J., Luczak, M., Kiefer, A.M., Niedner-Schatteburg, G., Manolikakes, G., Morgan, B. and Deponte, M.(2023)

Glutathione kinetically outcompetes reactions between dimedone and a cyclic sulfenamide or physiological sulfenic acids Free Radical Biology and Medicine 208,165-177

Knoke, L.R., Zimmermann, J., Lupilov, N., Schneider, J.F., Celebi, B., Morgan, B. & Leichert, L.I.(2023)

The role of glutathione in periplasmic redox homeostasis and oxidative protein folding in Escherichia coli Redox Biology 64:102800

Knöringer, K., Groh C., Krämer, L., Stein, K.C., Hansen, K.G., Zimmermann, J., Morgan, B., Herrmann, J.M., Frydman, J. and Boos, F.(2023)

The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering nonimported proteins Molecular Biology of the Cell 34(10):ar95

Lang, L., Wolf, A-C., Riedel, M., Thibol, L., Geissel, F., Feld, K., Zimmermann, J., Morgan, B., Manolikakes, G., & Deponte, M.(2023)

Substrate Promiscuity and Hyperoxidation Susceptibility as Potential Driving Forces for the Co-evolution of Prx5-Type and Prx6-Type 1-Cys Peroxiredoxin Mechanisms ACS Catalysis 13,3627-3642

Rodl, S., den Brave, F., Raschle, M., Kizmaz, B., Lenhard, S., Groh, C., Becker, H., Zimmermann, J., Morgan, B., Richling, E., Becker, T. & Herrmann, J. M.(2022)

The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import Life Science Alliance 6(1):e202201526

Hoehne, M. N., Jacobs, L., Lapacz, K. J., Calabrese, G., Murschall, L. M., Marker, T., Kaul, H., Trifunovic, A., Morgan, B., Fricker, M., Belousov, V. V. & Riemer, J.(2022)

Spatial and temporal control of mitochondrial H(2)O(2) release in intact human cells EMBO Journal 41,e109169

Duarte, M., Ferreira, C., Khandpur, G. K., Flohr, T., Zimmermann, J., Castro, H., Herrmann, J. M., Morgan, B. & Tomas, A. M.(2021)

Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I PNAS 118(42):e2103803118

Niemeyer, J., Scheuring, D., Oestreicher, J., Morgan, B. & Schroda, M.(2021)

Real-time monitoring of subcellular H2O2 distribution in Chlamydomonas reinhardtii Plant Cell 33,2935-2949

Zimmermann, J., Oestreicher, J., Geissel, F., Deponte, M. & Morgan, B.(2021)

An intracellular assay for activity screening and characterization of glutathione-dependent oxidoreductases Free Radical Biology and Medicine 340-349

Amponsah, P. S., Yahya, G., Zimmermann, J., Mai, M., Mergel, S., Muhlhaus, T., Storchova, Z. & Morgan, B.(2021)

Peroxiredoxins couple metabolism and cell division in an ultradian cycle Nature Chemical Biology 17(4):477-484 Image for Peroxiredoxins couple metabolism and cell division in an ultradian cycle

Image for Peroxiredoxins couple metabolism and cell division in an ultradian cycle

Vilas-Boas, E. A., Nalbach, L., Ampofo, E., Lucena, C. F., Naudet, L., Ortis, F., Carpinelli, A. R., Morgan, B. & Roma, L. P.(2021)

Transient NADPH oxidase 2-dependent H(2)O(2) production drives early palmitate-induced lipotoxicity in pancreatic islets Free Radical Biology and Medicine 162,1-13

Silina, Y. E. & Morgan, B.(2020)

LDI-MS scanner: Laser desorption ionization mass spectrometry-based biosensor standardization Talanta 223,121688

Steinbeck, J., Fuchs, P., Negroni, Y. L., Elsasser, M., Lichtenauer, S., Stockdreher, Y., Feitosa-Araujo, E., Kroll, J. B., Niemeier, J. O., Humberg, C., Smith, E. N., Mai, M., Nunes-Nesi, A., Meyer, A. J., Zottini, M., Morgan, B., Wagner, S. & Schwarzlander, M.(2020)

In Vivo NADH/NAD(+) Biosensing Reveals the Dynamics of Cytosolic Redox Metabolism in Plants Plant Cell 32, 3324-3345

Yap, Y. W., Rusu, P. M., Chan, A. Y., Fam, B. C., Jungmann, A., Solon-Biet, S. M., Barlow, C. K., Creek, D. J., Huang, C., Schittenhelm, R. B., Morgan, B., Schmoll, D., Kiens, B., Piper, M. D. W., Heikenwalder, M., Simpson, S. J., Broer, S., Andrikopoulos, S., Muller, O. J. & Rose, A. J.(2020)

Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution Nature Communications 11, 2894

Zimmermann, J., Oestreicher, J., Hess, S., Herrmann, J. M., Deponte, M. & Morgan, B*.(2020)

One cysteine is enough: A monothiol Grx can functionally replace all cytosolic Trx and dithiol Grx Redox Biology 36, 101598 Image for One cysteine is enough: A monothiol Grx can functionally replace all cytosolic Trx and dithiol Grx

Image for One cysteine is enough: A monothiol Grx can functionally replace all cytosolic Trx and dithiol Grx

Vilas-Boas, E. A., Karabacz, N., Marsiglio-Librais, G. N., Valle, M. M. R., Nalbach, L., Ampofo, E., Morgan, B., Carpinelli, A. R. & Roma, L. P.(2020)

Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic beta-cell physiology and function Pharmacology Reports 72, 1725-1737

Liedgens, L., Zimmermann, J., Waschenbach, L., Geissel, F., Laporte, H., Gohlke, H., Morgan, B*. & Deponte, M*.(2020)

Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins Nature Communications 11, 1725 Image for Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

Image for Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

Semenova, D., Gernaey, K. V., Morgan, B. & Silina, Y. E.(2019)

Towards one-step design of tailored enzymatic nanobiosensors Analyst 145, 1014-1024

Calabrese, G., Peker, E., Amponsah, P. S., Hoehne, M. N., Riemer, T., Mai, M., Bienert, G. P., Deponte, M., Morgan, B*. & Riemer, J*.(2019)

Hyperoxidation of mitochondrial peroxiredoxin limits H2 O2 -induced cell death in yeast EMBO Journal 38, e101552

Oestreicher, J. and Morgan, B*.(2018)

Glutathione: subcellular distribution and membrane transport Biochem Cell Biol. 97, 270-289

Roma, L. P., Deponte, M., Riemer, J. & Morgan, B.(2018)

Mechanisms and Applications of Redox-Sensitive Green Fluorescent Protein-Based Hydrogen Peroxide Probes Antioxidants Redox Signaling 29, 552-568

Calabrese, G., Morgan, B. & Riemer, J.(2017)

Mitochondrial Glutathione: Regulation and Functions Antioxidants Redox Signaling 27, 1162-1177

Staudacher, V., Trujillo, M., Diederichs, T., Dick, T. P., Radi, R., Morgan, B. & Deponte, M.(2017)

Redox-sensitive GFP fusions for monitoring the catalytic mechanism and inactivation of peroxiredoxins in living cells Redox Biology 14, 549-556

Yofe, I., Soliman, K., Chuartzman, S. G., Morgan, B., Weill, U., Yifrach, E., Dick, T. P., Cooper, S. J., Ejsing, C. S., Schuldiner, M., Zalckvar, E. & Thoms, S.(2017)

Pex35 is a regulator of peroxisome abundance Journal of Cell Science 130, 791-804

Swain, L., Kesemeyer, A., Meyer-Roxlau, S., Vettel, C., Zieseniss, A., Guntsch, A., Jatho, A., Becker, A., Nanadikar, M. S., Morgan, B., Dennerlein, S., Shah, A. M., El-Armouche, A., Nikolaev, V. O. & Katschinski, D. M.(2016)

Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice Circulation Research 119, 1004-1016

Schwarzländer, M., Dick, T.P., Meyer, A.J. & Morgan, B.(2016)

Dissecting Redox Biology Using Fluorescent Protein Sensors Antioxidants Redox Signaling 24, 680-712

Morgan, B., Van Laer, K., Owusu, T. N., Ezerina, D., Pastor-Flores, D., Amponsah, P. S., Tursch, A. & Dick, T. P*.(2016)

Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes Nature Chemical Biology 12, 437-43 Image for Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes

Image for Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes

Peralta, D., Bronowska, A. K., Morgan, B., Doka, E., Van Laer, K., Nagy, P., Grater, F. & Dick, T. P.(2015)

A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation Nature Chemical Biology 11, 156-63

Hildebrandt, T., Knuesting, J., Berndt, C., Morgan, B. and Scheibe, R.(2015)

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub? Biological Chemistry 396, 523-37

Elbaz-Alon, Y., Morgan, B., Clancy, A., Amoako, T. N., Zalckvar, E., Dick, T. P., Schwappach, B. & Schuldiner, M.(2014)

The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis FEMS Yeast Research 14, 1055-67

Schwarzlander, M., Wagner, S., Ermakova, Y. G., Belousov, V. V., Radi, R., Beckman, J. S., Buettner, G. R., Demaurex, N., Duchen, M. R., Forman, H. J., Fricker, M. D., Gems, D., Halestrap, A. P., Halliwell, B., Jakob, U., Johnston, I. G., Jones, N. S., Logan, D. C., Morgan, B., Muller, F. L., Nicholls, D. G., Remington, S. J., Schumacker, P. T., Winterbourn, C. C., Sweetlove, L. J., Meyer, A. J., Dick, T. P. & Murphy, M. P.(2014)

The 'mitoflash' probe cpYFP does not respond to superoxide Nature 514, E12-4

Morgan, B.(2014)

Reassessing cellular glutathione homoeostasis: novel insights revealed by genetically encoded redox probes Biochemical Society Transactions 42, 979-84

Ezerina, D., Morgan, B. and Dick, T. P.(2014)

Imaging dynamic redox processes with genetically encoded probes Journal of Molecular and Cellular Cardiology 73, 43-9

Bode, M., Longen, S., Morgan, B., Peleh, V., Dick, T. P., Bihlmaier, K. & Herrmann, J. M.(2013)

Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest Antioxidants Redox Signal 18, 1597-612

Morgan, B., Ezerina, D., Amoako, T. N., Riemer, J., Seedorf, M. & Dick, T. P.(2012)

Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis Nature Chemical Biology 9, 119-25 Image for Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis

Image for Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis

Kojer, K., Bien, M., Gangel, H., Morgan, B., Dick, T. P. & Riemer, J.(2012)

Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state EMBO Journal 31, 3169-82

Morgan, B., Sobotta, M.C. and Dick, T.P.(2011)

Measuring E(GSH) and H2O2 with roGFP2-based redox probes Free Radical Biology and Medicine 51, 1943-51

Braun, N. A*., Morgan, B., Dick, T. P. & Schwappach, B.(2010)

The yeast CLC protein counteracts vesicular acidification during iron starvation Journal of Cell Science 123, 2342-50

Morgan, B., Ang, S. K., Yan, G. & Lu, H.(2008)

Zinc can play chaperone-like and inhibitor roles during import of mitochondrial small Tim proteins Journal Biological Chemistry 284, 6818-25

Morgan, B. & Lu, H.(2008)

Oxidative folding competes with mitochondrial import of the small Tim proteins Biochemical Journal 411, 115-22

RESEARCH ARTICLES

BOOK CHAPTERS